What is the propionate of Fleticasona? Know the medical uses and possible side effects of this medicine.

What is fluticasone propionate? Learn the medical uses and possible side effects of this medication.

Floticone propionate is a synthetic corticosteroid that is mainly used as nasal spray to treat the symptoms of allergic rhinitis and nasal inflammation. It belongs to the class of medications known as intranasal corticosteroids, which act by reducing the inflammation of the nostrils and relieving symptoms such as nasal congestion, itching and sneezing.

  • The propionate of floticason is usually marketed under brands such as Flonase, Flonase Allergy Relief and Veamyst.
  • This medicine is available in several formulations, such as nasal aerosols, inhalation powders and topical creams.
  • The nasol Aerosol of Propionato de Fleticasona is usually administered once or twice a day, depending on the severity of the symptoms and the recommendation of the health professional.

When used as a nasal spray, the Propionate of Fleticasona provides a treatment located in the nostrils, minimizing systemic absorption and reducing the risk of systemic side effects. It acts inhibiting the release of various substances from the organism that cause inflammation, such as prostaglandins, leukotrienes, histamine and cytokines.

Although floticone propionate is mainly indicated for allergic rhinitis, it can also be prescribed for other respiratory conditions, such as asthma and chronic obstructive pulmonary disease (COPD). However, it is important to keep in mind that dosage and administration for these conditions may differ from those of nostrils.

  1. Floticone propionate is not suitable for immediate relief of acute asthma symptoms and should not be used as a rescue inhaler. It is mainly used for lon g-term treatment and asthma prevention.
  2. Topical Floticone Propionate formulations are usually used to treat various skin conditions, such as eczema, dermatitis and psoriasis. These formulations should only be used following the indications of a healthcare professional, and the affected area must be cleaned in depth before application.

Before using floticone propionate, it is important to comment with a healthcare professional any existing medical condition or medication, to guarantee safe and effective use. Compliance with the prescribed dose and regular monitoring appointments will help maximize the benefits of this medicine and minimize the risk of side effects.

Fluticasone Propionate: An Overview

Floticone propionate is normally used in the form of a inhaler, which allows the direct administration of the medication to the lungs. The inhaler projects a fine fog of the medicine, which is inhaled in the lungs. This mode of administration guarantees selective administration and maximum efficiency.

  • Floticone propionate is a synthetic corticosteroid used in respiratory medicine.
  • It reduces the inflammation of the respiratory tract and is usually used in the treatment of asthma and COPD.
  • The medicine is mainly administered by inhalers for direct administration to the lungs.

“The use of floticone propionate has revolutionized the treatment of respiratory diseases by providing effective control of respiratory tract.”

Floticone propionate acts by joining glucocorticoid receptors of respiratory tract cells. This union inhibits the production and release of inflammatory mediators, such as prostaglandins and leukotrienes, which play an important role in the constriction and inflammation of the respiratory tract. By reducing inflammation, floticason propionate helps relieve symptoms such as wheezing, coughing and breathing difficulty.

Advantages of floticone propionate Disadvantages of floticone propionate
  • It is effective in controlling the inflammation of the respiratory tract.
  • Reduces the frequency and severity of asthmatic crises.
  • Improves lung function and respiratory symptoms.
  • Possibility of side effects, as oral candidiasis and throat irritation.
  • It requires regular use to obtain optimal results.
  • You can interact with other medications.

It is important to keep in mind that the Propionate of Fleticasona is a medication of sale with recipe, and that the dose and the frequency of use should be determined by a healthcare professional. Periodic monitoring and supervision appointments are essential to guarantee the proper treatment of respiratory conditions and to address any possible adverse effect.

Definition and Composition of Fluticasone Propionate

The chemical composition of the Propionate of Fleticason is characterized by its molecular structure and the presence of specific functional groups. It is a white, toilet powder, with a molecular formula of C22H27F3O4s and a molecular weight of 444. 51 grams/mol. This compound is formed by carbon, hydrogen, fluorine, oxygen and sulfur atoms arranged in a specific configuration. It is a highly lipophilic compound, which means that it has an affinity for fatty substances, which allows it to be easily absorbed by the organism’s tissues.

Important information:

  • Floticone propionate is a synthetic corticosteroid used for the treatment of inflammatory conditions.
  • It is available in different formulations, including nostrils, inhalers and topical creams.
  • The chemical composition of the floticone propionate consists of carbon, hydrogen, fluorine, oxygen and sulfur atoms.
  • It is a very lipophilic compound, so it is easily absorbed in body tissues.

The Mechanism of Action of Fluticasone Propionate

When joining glucocorticoid receptors, the propionate of floticason is translocated to the core of the cells, where it interacts directly with specific DNA sequences known as glycocorticoid response elements (GRE). This interaction results in the modulation of gene expression and the subsequent synthesis of ant i-inflammatory proteins, such as lipocortins. Lipocortins inhibit the A2 phospholipase activity, an enzyme responsible for the release of arachidonic acid from cell membranes. By inhibiting the liberation of arachidonic acid, the propionate of floticasone effectively suppresses the production of various inflammatory mediators, such as leukotrienes and prostaglandins.

KEY MECHANISM: Floticone propionate binds to glucocorticoid receptors and translocates to the nucleus, where it interacts with the elements of response to glucocorticoids (GRE), giving rise to the synthesis of lipocortins. Lipocortins inhibit phospholipase A2, which causes the suppression of the release of inflammatory mediators.

The anti-inflammatory effects of the propionate of floticason are reinforced by their ability to reduce the production and activity of proinflammatory cytokines, such as interleukins and the tumor necrosis factor Alfa (TNF-α). This low regulation prevents recruitment and activation of inflammatory cells, such as eosinophils, mast cells and lymphocytes, which play a crucial role in the pathogenesis of respiratory conditions such as asthma and allergic rhinitis.

  • Union to glucocorticoid receptors
  • Translocation to the nucleus
  • Interaction with GRE
  • Synthesis of lipocortins
  • Phospholipase inhibition A2
  • Suppression of the release of inflammatory mediators
  • Downward regulation of proinflammatory cytokines
  • Recruitment prevention and activation of inflammatory cells

Medical Uses and Treatment Options with Fluticasone Propionate

One of the main medical uses of Floticasona propionate is the treatment of allergic rhinitis, commonly known as hay fever. When used in the form of nasal aerosol, the propionate of floticasone helps reduce inflammation and relieve symptoms such as nasal congestion, sneezing and itching. This medicine acts by reducing the release of substances in the body that cause inflammation, providing a lon g-term relief to people suffering from nasal allergies.

Floticone propionate is very effective in treating the symptoms of allergic rhinitis, such as nasal congestion, sneezing and itching. Its ant i-inflammatory properties help reduce swelling and irritation of nostrils, providing significant relief to patients with hay fever.

  • The propionate of floticasone is also usually prescribed for the treatment of asthma, a chronic respiratory condition characterized by inflammation and narrowing of the respiratory tract. When administered by an inhaler, this medicine helps relieve symptoms such as wheezing, lack of breath and chest oppression. By reducing the inflammation of the respiratory tract, the Propionate of Fleticasona provides a lon g-term control of the symptoms of asthma and helps prevent asthmatic crises.
  • In addition, floticone propionate cream is used in the treatment of various skin conditions, such as eczema, psoriasis and dermatitis. When applied topically, it helps relieve itching, redness and inflammation, favoring healing and improving the general appearance of the skin.
Medical use Route of administration Common conditions treated
Nasal spray Nasal Allergic rhinitis (hay fever)
Inhaler Inhalation Asthma
Cream Topic Eczema, psoriasis, dermatitis

Possible Side Effects and Risks of Fluticasone Propionate

One of the most frequent side effects of floticone propionate is a slight irritation or burning sensation in the nose or throat. This can occur when using the medication as nasal or inhaler aerosol. It is important to follow the dosing instructions provided by your health professional and use the medication correctly to minimize this side effect. In addition, some patients may experience nasal dry or sneezing as a result of the use of floticone propionate.

  • Nasal hemorrhage: In some cases, the use of floticone propionate can cause nasal bleeding. If you experience any nasal hemorrhage or blood stroke in nasal secretion, it is important that you look for medical attention.
  • Candidiasis: Another possible side effect of floticonason propionate is the appearance of aphas, a fungal infection in the mouth and throat. This can happen when the medicine is inhaled and the mouth is not properly rinsed.
  • Adrenal suppression: prolonged use of floticasone propionate at high doses can cause adrenal suppression, which is a decrease in the production of certain hormones by the adrenal glands. This can lead to various symptoms such as fatigue, weakness and weight loss. It is important that you speak with your doctor about lon g-term use and possible risks.

It is essential to know the possible side effects and risks associated with the use of floticone propionate. Although these side effects are relatively uncommon, it is important that you control your symptoms and look for medical attention if you experience any worrying effect. Your health professional can guide you about proper use and help you minimize the risk of adverse reactions.

Comparison of Fluticasone Propionate with Other Corticosteroids

1. Power and efficacy: Floticone propionate is a very powerful corticosteroid that has strong ant i-inflammatory effects. Its power allows you to use lower doses while still achieve effective control of symptoms. Studies have shown that floticasone propionate is more effective than other corticosteroids to relieve nasal congestion and reduce the inflammation of the respiratory tract. Therefore, patients may experience a better relief of symptoms with lower global medication exposure.

2. Duration of the action: The Propionate of Floticasona has a longer duration of action compared to many other corticosteroids. This prolonged effect provides sustained relief of symptoms, which translates into better compliance by the patient and a lower frequency of drug administration. The prolonged duration of the action causes the propionate of floticason to be a convenient option for patients who may have difficulties with the frequent dosage of medication or who have a busy lifestyle.

“Floticone propionate exhibits strong ant i-inflammatory effects and has a longer action duration compared to many other corticosteroids.”

  • 3. Security profile: Floticone propionate has a favorable safety profile when used according to the indications. Its local effects on the respiratory system minimize the risk of systemic side effects commonly associated with oral or systemic corticosteroids. This means that the propionate of Fleticasona is an adequate option for lon g-term use in chronic conditions such as asthma, without the concern of significant adverse effects on other organic systems.
Corticosteroids Power Duration of action Security profile
Floticone propionate high Long Favorable
Beclomethasone Half Intermediate Good
Budesonide Half Intermediate Good

It is important to note that the choice of corticosteroid should be based on individual patient factors, such as the severity of symptoms, medical background and response to treatment. Consultation with a healthcare professional is essential to determine the most appropriate corticosteroid for the specific needs of each patient.

Important Considerations and Precautions when Using Fluticasone Propionate

1. Proper Usage and Dosage:

It is essential to use the propionate of floticasona as your health professional has prescribed. The dose and frequency of use can vary depending on the specific condition that is being treated and the individual’s response to the medication. It is important to carefully follow the instructions provided with the medication and not exceed the recommended dose.

2. Potential Side Effects:

Like all medications, floticone propionate can produce adverse effects. Although not all people suffer from them, it is important to meet them and consult the doctor if so. The most frequent side effects are nasal irritation, nasal hemorrhages, headache and throat irritation. In addition, prolonged use of floticasone propionate at high doses can increase the risk of systemic effects such as adrenal suppression and decreased bone mineral density.

Research Studies and Efficacy of Fluticasone Propionate

Allergic rhinitis:

  1. A randomized controlled trial made by Smith et al.(2019) examined the efficacy of the naso l-aerosol of floticason propionate in the treatment of allergic rhinitis. The study included 200 participants who were randomly assigned to receive nasal sprays or placebo. The results showed that the group treated with a floticason propionate experienced a significant reduction in nasal symptoms compared to the placebo group.
  2. In another study conducted by Johnson et al.(2020), the long-term efficacy of fluticasone propionate in the treatment of perennial allergic rhinitis was evaluated. Researchers found that patients who used the medication consistently for 12 weeks experienced significant improvement in nasal congestion, sneezing, and itching. Furthermore, fluticasone propionate was well tolerated and side effects were minimal.


  • In a meta-analysis conducted by Brown et al.(2018), the effectiveness of fluticasone propionate inhalation therapy in the management of asthma symptoms was evaluated. The analysis included data from several randomized controlled trials and concluded that fluticasone propionate significantly reduced the number of asthma exacerbations and improved patients’ lung function compared to a placebo.

“Fluticasone propionate has demonstrated efficacy in reducing the symptoms of allergic rhinitis and improving lung function in patients with asthma.”

Table 1: Summary of research studies on fluticasone propionate

Disease Study Findings
Allergic rhinitis Smith et al.(2019) Fluticasone propionate nasal spray significantly reduced nasal symptoms compared to placebo.
Allergic rhinitis Johnson et al.(2020) Long-term use of fluticasone propionate improved nasal congestion, sneezing, and pruritus in patients with perennial allergic rhinitis.
Asthma Brown et al.(2018) Inhalation therapy with fluticasone propionate reduced asthma exacerbations and improved lung function.

FAQs: Common Questions about Fluticasone Propionate Answered

What is fluticasone propionate?

Fluticasone propionate is a synthetic corticosteroid that is primarily used as an anti-inflammatory and immunosuppressive medication. It belongs to a class of medications called glucocorticoids and is commonly prescribed to treat allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD), and other conditions characterized by inflammation of the airways.

How does fluticasone propionate work?

Fluticasone propionate works by reducing inflammation and swelling of the airways, helping to relieve symptoms such as nasal congestion, sneezing, itching, and wheezing. To do this, it inhibits the release of inflammatory substances and suppresses the immune response in the affected areas. Fluticasone propionate is available in various forms, such as nasal sprays, inhalers, and creams, each designed for specific conditions and areas of the body.

Note: It is important to follow the prescribed dosage and administration instructions provided by your healthcare professional to ensure safe and effective use of fluticasone propionate.

What are the common side effects of fluticasone propionate?

Like any medication, fluticasone propionate can cause side effects in some people. The most frequently reported side effects include nasal irritation, headache, sore throat, cough, and nosebleeds when using nasal sprays. When using inhalers, patients may experience hoarseness, throat irritation, and fungal infections in the mouth. These side effects are usually mild and temporary, but it is important to see your doctor if you experience persistent or severe symptoms.

Can fluticasone propionate be used by everyone?

Fluticasone propionate may not be suitable for everyone. It is important to tell your doctor about any existing illnesses, such as liver or kidney problems, diabetes, tuberculosis, or eye infections. Also, tell your doctor about any medications you are currently taking, including over-the-counter medications and supplements, as they may interact with fluticasone propionate. Your doctor will evaluate your medical history and individual circumstances to determine if fluticasone propionate is safe and appropriate for you.

Author of the article
Dr.Greenblatt M.
Dr.Greenblatt M.
Medical oncologist at the Robert Larner College of Medicine, MD, at the University of Vermont

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