The connection between azelastine and blood pressure – explore the potential impact of this medication on cardiovascular health.

The connection between azelastine and blood pressure - explore the potential impact of this medication on cardiovascular health.

Azelastine is a commonly prescribed antihistamine that is primarily used to relieve allergy symptoms, such as a runny nose, sneezing, and itchy or watery eyes. However, concern has been expressed about its possible effects on blood pressure. Understanding the relationship between azelastine and blood pressure is crucial for patients with hypertension or at risk for hypertension.

Research studies have explored the possible impact of azelastine on blood pressure levels. Although the available scientific evidence is limited, some studies suggest that azelastine may modestly raise blood pressure in certain individuals. A study published in the Journal of Clinical Hypertension found that azelastine nasal spray caused a small but significant increase in systolic blood pressure in patients with allergic rhinitis.

Summary of studies investigating the effects of azelastine on blood pressure
Study Participants Results
Journal of Clinical Hypertension (2020) Patients with allergic rhinitis Azelastine nasal spray produced a small but significant increase in systolic blood pressure

“Although azelastine may cause a slight elevation in blood pressure, this effect is generally well tolerated and does not pose a significant risk for most individuals. However, it is important that patients with pre-existing hypertension or those at risk of cardiovascular complicationsConsult your healthcare professional before using azelastine.”

Information about azelastine and its uses

The Role of Azelastine in Medical Treatment

Azelastine Uses:

  • Azelastine nasal spray: This form of azelastine is primarily used to treat nasal symptoms caused by seasonal allergic rhinitis or hay fever. It works by reducing inflammation of the nasal passages and blocking the release of histamines, responsible for allergic reactions.
  • Azelastine eye drops: Azelastine eye drops are used to relieve the symptoms of allergic conjunctivitis, commonly known as eye allergy. Helps relieve itchy, red, and watery eyes caused by allergic reactions.

Note: It is important to follow the prescribed dosage and instructions for use provided by your healthcare professional when using azelastine. Improper use may lead to less effective treatment or possible side effects.

Possible side effects:

  1. Somnolence: Azelastina can cause drowsiness. It is advisable to refrain from driving or handling heavy machinery until you know how this medicine affects you.
  2. Dry mouth or throat: Some individuals may experience dry mouth or throat after using azelastina. Drinking water or sugarless candy can help relieve this symptoms.
  3. Nasal irritation: In some cases, Nasal Azelastina aerosol can cause mild nasal irritation or a temporary ardor sensation. This is usually resolved by itself. If irritation persists or worsens, it is recommended to consult a healthcare professional.
Common brands Formulations
Astelin Nasal spray
Optivate Ophthalmic drops

The Relationship Between Blood Pressure and Azelastine

An important study by Smith et al.(2018) aimed to investigate the impact of ocelaastin on blood pressure on a randomized controlled trial that included 200 participants. The participants in the study were divided into two groups, one of whom received azelastin in nasal spray and the other a placebo. The researchers controlled the blood pressure levels of the participants for a period of 12 weeks and observed the changes that occurred.

The study results revealed that the participants who used the Nasal Azelastina aerosol experienced a slight increase in systolic blood pressure compared to the placebo group. Systolic blood pressure is the highest figure in a reading of blood pressure and represents the force exerted on the arterial walls during heartbeat. The difference in systolic blood pressure between the groups was statistically significant, but not clinically significant, indicating that the increase observed was lower and it is unlikely that it has a significant impact on the general control of blood pressure.

Possible Mechanisms for Blood Pressure Changes

Although the exact mechanism by which azelastin can affect blood pressure is not known, researchers have proposed several theories. A possible explanation is that azelastin, being an antihistamine, can cause vasoconstriction, which is the narrowing of blood vessels. This constriction could cause a temporary increase in blood pressure. However, more studies are needed to confirm this hypothesis and explore the precise mechanisms involved.

  1. References:
    1. Smith J, et al.(2018) The effects of azelastin on blood pressure: a randomized controlled trial. Magazine of Allergy and Clinical Immunology, 142 (4): 123-129.

Clinical studies on the effects of azelastine on blood pressure

One of the most prominent studies on this subject was the one conducted by Smith et al.(2015) with a sample of 500 participants. The objective of the study was to determine if the azelastin had some significant effect on blood pressure compared to a placebo. The participants were randomly distributed in two groups: one that received Azelastina and another that received a placebo. The duration of the study was 6 weeks, during which blood pressure measurements were made at regular intervals.

The results of the Smith et al.(2015) indicated that there were no significant differences in blood pressure levels between the Azelastina group and placebo at the end of the 6-week period. Both systolic and diastolic blood pressure remained within normal ranges for both groups, which suggests that azelastin does not have a clinically significant impact on blood pressure.

Another study by Johnson et al.(2018) aimed to investigate the effects of the lon g-term use of azelastin in blood pressure. The study included 200 participants who were monitored for 12 months. Blood pressure measurements were taken at regular intervals during the entire study period. The results of this study also indicated that there was no significant increase in blood pressure levels among participants who used Azelastin compared to a control group.

Potential mechanisms behind azelastine’s impact on blood pressure

1. Blocking of α-adrenergic receptors: It has been shown that azelastin has blocking properties of α-adrenergic receptors, which can contribute to its effect on blood pressure. Α-adrenergic receptors play a role in the regulation of peripheral vascular resistance, and the blocking of these receptors can produce vasodilation and the consequent decrease in blood pressure. However, the exact scope of the blocker effect of α-adrenergic receptors of azelastin and its clinical significance in terms of blood pressure modulation are still to be elucidated.

“Azelastina has blocking properties of α-adrenergic receptors, which can influence blood pressure regulation.”

2. Histamine H1 receptor antagonism: Azelastin exerts its antihistamine effects mainly through its H1 H1 receptor antagonism. It is known that histamine intervenes in the contraction of vascular smooth muscle and in the regulation of blood pressure. By blocking H1 H1 of histamine receptors, azelastin can indirectly influence blood pressure. However, the direct relationship between the histamine receptor block and the changes in blood pressure caused by azelastin requires more research.

3. ADDITIONAL FACTORS: It is important to point out that there are other factors that can interact with the potential effects of azelastin on blood pressure. For example, the concomitant use of other medications, the individual characteristics of the patient (for example, age, pr e-existing diseases) and dosing regimes can influence the global impact on blood pressure. Therefore, an exhaustive understanding of the mechanisms of action of the azelastin, including its possible interactions with other physiological processes, is crucial to accurately evaluate its effect on blood pressure.

Considerations for individuals with pre-existing hypertension

Lifestyle modifications

  • The adoption of a healthy diet, low in sodium and rich in fruits, vegetables and integral cereals, can help control blood voltage levels.
  • Regular physical activity, such as walking at a light pace or swimming, can contribute to weight loss and, ultimately, to reduce blood pressure.
  • Avoiding tobacco products and limit alcohol consumption are essential for people with hypertension.
  • Stress control techniques, such as relaxation or meditation exercises, can help reduce blood pressure levels.

Considerations on medication

In the case of people with pr e-existing hypertension, some medications should be evaluated and controlled carefully in consultation with the healthcare professional.

  • Some medications, such as no n-steroidal ant i-inflammatories (NSAIDs) or decongestants, can temporarily raise blood pressure and should be used with caution.
  • Antihistamines, including azelastin, are usually used for allergies or nasal congestion. Although studies suggest that azelastin does not significantly raise blood pressure, it is important that people with hypertension are consult with their doctor.
Key points
People with pr e-existing hypertension must adopt a healthy lifestyle, which includes a low sodium diet and regular physical activity, to control their blood pressure levels.
Control stress and avoid tobacco and excessive alcohol consumption are equally important to maintain optimal blood voltage levels.
Medications that may affect blood pressure should be evaluated and controlled in consultation with a healthcare professional.

Discussing the risks and benefits of azelastine with your healthcare provider


  • Increased blood pressure: A potential risk associated with the use of azelastin is an elevation of blood pressure. Although this antihistamine generally does not have a significant effect on blood pressure, some individuals may experience a slight increase. It is essential that people with hypertension or other cardiovascular diseases consult this risk with their doctor before starting to take azelastina.
  • Drug interactions: Like any other medicine, azelastin can interact with other medications you are taking. It is very important that you inform your doctor of all the medications you are taking, whether prescribed, free sale or herbal supplements. They can evaluate the possible interactions to guarantee the safe and effective use of azelastin.
  • Allergic reactions: Although it is rare, some people may experience an allergic reaction to the nasal Azelastin sprays. This may include symptoms such as urticaria, itching, swelling or difficulty breathing. If any of these signs occurs, it is important to seek immediate medical attention.


The nasal spray of azelastin relieves the symptoms of allergy blocking the effects of histamine, a substance produced by the organism in response to allergens. By inhibiting the action of histamine, azelastin helps relieve symptoms such as sneezing, itching and nasal dripping. This medicine can be especially effective in treating seasonal allergies and allergic rhinitis.

If you talk about the risks and benefits of Azelastina with your doctor, you can make an informed decision about its use to treat the symptoms of allergy. The doctor will take into account your medical history, your current medication and your personal circumstances to determine whether the azelastina is the right option for you.

Monitoring Blood Pressure while Taking Azelastine

Bloo d-voltage control: regular blood pressure control is essential for people who take azelastin. Changes in blood pressure can be produced as a side effect of this medication, and it is important to control any fluctuation to ensure that blood pressure is maintained within normal limits. Blood pressure can be measured with a tensiometer, which can be acquired for domestic use or performed in a clinic or in the consultation of a healthcare professional.

It is recommended to control blood pressure before starting to take azelastina and periodically throughout the treatment.

Use of an UL blocker:

  • Control blood pressure at least once a week initially
  • Once blood pressure is stabilized, monthly monitoring may be sufficient.
  • If there are any concerns or symptoms of high or low blood pressure, immediate monitoring is recommended

Use an ol block:

  1. Place the blood pressure cuff on your upper arm
  2. Place your arm at heart level
  3. Inflate the cuff until it reaches a pressure higher than the expected systolic pressure
  4. Slowly release the pressure while listening to the pulse sound
  5. Write down both systolic and diastolic pressure

Table summarizing recommendations for blood pressure control:

Treatment stage Monitoring Frequency
Before starting azelastine Basal measurement
Initial weeks of treatment At least once a week
Stabilized blood pressure Monthly control
Concern or symptoms of changes in blood pressure Immediate control

Author of the article
Dr.Greenblatt M.
Dr.Greenblatt M.
Medical oncologist at the Robert Larner College of Medicine, MD, at the University of Vermont

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