Trazodona 75 mg is a drug widely used in the field of psychiatry. It is mainly prescribed for the treatment of depression and anxiety disorders. The trazodone belongs to a class of medications known as serotonin receptors and reuptake inhibitors (SARI). It acts by restoring the balance of certain natural substances in the brain, thus providing relief of the symptoms associated with these disorders.
Important information:
Trazodona 75 mg should be taken exactly as prescribed by your doctor. It is important to follow the recommended dose and treatment duration to achieve optimal results.
The trazodone is normally presented in the form of tablets and each tablet contains 75 mg of the active substance. These tablets are usually taken orally, with or without food. It is generally recommended to take the trazodone when bedtime to minimize possible side effects, such as drowsiness or dizziness.
- Possible side effects:
- Precautions and warnings:
- Special populations:
Like any medicine, 75 mg trazodone can cause certain side effects. The most frequent side effects are drowsiness, headache, blurred vision, constipation and dry mouth. It is important that you inform your doctor if any of these side effects persists or worsens.
Before starting to take 75 mg trazodone, it is important that you inform your medical care provider about any medical condition, allergy or medication that you are currently taking. Trazodone can interact with certain medications, such as monoamineoxidase (IMAO) inhibitors, and should not be taken in the 14 days of the interruption of an IMAO.
Trazodone 75 mg should be used with caution in older adults and individuals with liver or renal alterations. In these cases it may be necessary to adjust the dose or the frequency of administration.
| Tradename | Generic name | Dose |
|---|---|---|
| Trazodone | Trazodone hydrochloride | 75 mg |
Trazodone 75 mg: Mechanism of Action
1. serotonergic effects: Trazodone functions as a serotonin modulator and reuptake inhibitor (SRI). It exerts its main therapeutic effect by selectively inhibiting serotonin reuptake in the brain, thus increasing serotonergic neurotransmission. This improves the signaling of serotonin, a neurotransmitter known for playing a crucial role in mood regulation, sleep and other cognitive functions.
“Selective serotonin reuptake inhibitors are a kind of drugs used to treat depression by selective inhibition of the reuptake of serotonin neurotransmitter in the brain.”
2. Antagonism of certain receptors: Trazodone also has antagonistic activity in several receptors, including certain serotonin receptors (5-HT2A, 5-HT2C), alpha-1 adrenergic receptors and H1 histamine receptors. When blocking these receptors, the medicine helps modulate neurotransmission in various ways and systems, which contributes to their therapeutic efficacy. This broad profile of receivers distinguishes the trazodone of other antidepressants, providing potential benefits by addressing the multifaceted nature of depression and associated symptoms.
- Note: The antagonism of 5-HT2A receptors has been involved in the sedative properties of trazodone, which can be beneficial in the management of insomnia in individuals with depression.
- Note: The antagonism of adrenergic alpha-1 receptors can contribute to the minimum anticholinergic side effects of trazodone compared to other antidepressants.
- Note: The antagonism of histamine H1 receptors can explain the potential of trazodone to cause drowsiness, particularly at higher doses.
3. ADDITIONAL MECHANISMS: Although serotonergic and antagonism effects of receptors are the main mechanisms, trazodone can also interact with other neurotransmitter systems, such as dopamine and norepinephrine, although to a lesser extent. These interactions also contribute to their global pharmacological activity and their therapeutic effects. However, the precise understanding of these additional mechanisms remains an ongoing research area.
| Key action mechanisms: |
|---|
| – Selective inhibition of serotonin reuptake. |
| -Specific receptor antagonism, including 5-HT2A, 5-HT2C, Alfa-1 adrenergic and histamine H1 receptors. |
| – Possible interaction with dopaminergic and norepinephrine systems. |
Uses and Indications of Trazodone 75 mg
One of the main use of 75 mg trazodone is the treatment of depression. Depression is a frequent mental disorder characterized by persistent feelings of sadness, loss of interest in activities and general lack of energy. Trazodone acts by increasing serotonin levels in the brain, a neurotransmitter that plays a key role in mood regulation. This helps relieve the symptoms of depression and improve general mood.
Important information:
- The trazodone should not be taken by allergic people or with a history of hypersensitivity reactions to other SITS.
- Trazodone may take several weeks to reach full efficacy, so patients should continue to take the medication as prescribed even if they begin to feel better.
- Patients should not stop taking trazodone abruptly without consulting their doctor, since this can cause withdrawal symptoms. The dose should be gradually reduced under medical supervision.
In addition to its antidepressant properties, 75 mg trazodone is also used outside indication for the treatment of insomnia. Insomnia is a sleep disorder characterized by the difficulty in reconciling sleep or staying asleep throughout the night. The sedative effects of trazodone can help reconcile sleep and improve its quality. It is often prescribed in lower doses for slee p-related problems.
| Condition | Recommended dose | Grades |
|---|---|---|
| Major depressive disorder | 75 mg (can vary) | A gradual dose adjustment may be necessary |
| Anxiety disorders | 75 mg (can vary) | It is recommended to consult the doctor |
| Insomnia | 25-50 mg (Use not indicated) | You can prescribe lower doses for slee p-related problems |
Dosage and Administration
Posology:
- The recommended initial dose of adult trazodone is 75 mg per day, normally prescribed in divided doses.
- Depending on the individual response and tolerability, the dose can be gradually increased by your doctor at weekly intervals.
- For maintenance treatment, the usual effective dose ranges between 150 and 600 mg per day.
It is important to keep in mind that, although 75 mg is a common initial dose, it may vary depending on the specific disease being treated. Always consult your healthcare professional to obtain personalized dosage recommendations.
Administration:
- Be sure to read the medication guide or the prospect provided by the pharmacist before taking 75 mg trazodone.
- Swallow the entire tablet and do not crush it, mast or break.
- If you have difficulty swallowing, consult your doctor about alternative methods of administration.
- It is recommended to take Trazodone at the same time each day to create a habit and minimize the chance of missing a dose.
Possible Side Effects
1. Common side effects:
- Headaches
- Dizziness
- Drowsiness
- Nausea
- Vomiting
These side effects are relatively common and usually subside as the body adapts to the medication. However, if they become severe or bothersome, it is recommended to consult your doctor for further guidance.
2. Rare but serious side effects:
- Allergic reactions: Some individuals may experience an allergic reaction to Trazodone, characterized by symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing. If you notice any of these symptoms, seek immediate medical attention.
- Priapism: This is a condition characterized by prolonged and painful erections that can occur in men. It is a rare side effect of Trazodone, but if left untreated, it can cause permanent damage. If you experience a prolonged and painful erection, seek immediate medical help.
It is important to note that this is not an exhaustive list of possible side effects. Other less common side effects may occur. Always follow your doctor’s instructions and report any unusual symptoms or concerns immediately.
Note: This medication guide does not contain all possible side effects of Trazodone. Consult your doctor or pharmacist for more information.
Drug Interactions
Types of drug interactions:
- Pharmacodynamic interactions: These interactions occur when drugs with similar mechanisms of action are used together. For example, when Trazodone 75 mg, an antidepressant, is taken with other medications that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs), there is an increased risk of serotonin syndrome.
- Pharmacokinetic interactions: These interactions occur when one drug affects the metabolism, absorption, distribution, or elimination of another drug. Trazodone, for example, is primarily metabolized by the liver enzyme CYP3A4. Therefore, drugs that inhibit or induce CYP3A4 may affect trazodone levels in the body.
- Drug-Food Interactions: Some medications may interact with certain foods, beverages, or dietary supplements. This may affect the absorption or metabolism of the medication. For example, grapefruit juice may inhibit the CYP3A4 enzyme, which may increase the concentration of Trazodone in the blood.
Important note: It is essential that healthcare professionals and people taking medications communicate openly about all the drugs they are using, including prescription, over-the-counter, and herbal supplements. This allows for a thorough evaluation of potential drug interactions and allows for appropriate adjustments to medication regimens.
| Interacting drug | Interaction effect |
|---|---|
| SSRIs (for example, fluoxetine) | Increased risk of serotonin syndrome |
| Ketoconazole (CYP3A4 inhibitor) | Elevated levels of trazodone, which may cause increased side effects. |
| Rifampicin (CYP3A4 inducer) | Reduced levels of Trazodone, potentially reducing its effectiveness |
Precautions and Warnings
1. Allergic reactions:
People who have experienced allergic reactions to any of the components of the medication should avoid taking Trazodone 75 mg. Allergic reactions may include rash, itching, swelling, severe dizziness, or difficulty breathing. If any of these symptoms occur, immediate medical attention is necessary.
2. Suicidal thoughts:
Trazodone 75 mg is primarily used to treat depression, and it is important to note that the risk of suicidal thoughts or behavior may increase, especially in young adults or people with a history of mental disorders. Close monitoring by a healthcare professional is essential during the initial period of treatment and when the dose is adjusted.
3. Interactions with other medications:
Trazodone 75 mg may interact with certain medications, including but not limited to monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), and other antidepressants. These interactions can cause potentially serious side effects, such as serotonin syndrome. It is important to tell your doctor about all medications you are taking to avoid harmful interactions.
Important: It is essential to follow the exact dosage and administration instructions provided by your healthcare professional to ensure the safe and effective use of Trazodone 75 mg. Do not exceed the prescribed dose or abruptly stop medication without consulting your healthcare professional. Any changes should be made under the supervision and guidance of a medical professional.
In general, Trazodone 75 mg can be an effective treatment for depression and some other conditions. However, it is important to take precautions and be aware of the potential risks, especially when it comes to allergies, suicidal thoughts, and interactions with other medications. By being cautious and informed, individuals can ensure appropriate use of Trazodone 75 mg and minimize any potential adverse effects.
