Find out what ibrufen is, its uses, possible side effects, and how it can help relieve pain and inflammation in various conditions.

Discover what Ibrufen is, its uses, possible side effects and how it can help relieve pain and inflammation in various conditions.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to relieve pain, reduce inflammation, and reduce fever. It is sold under various brand names, such as Advil and Motrin. Ibuprofen works by inhibiting the production of hormones called prostaglandins, responsible for inflammation and pain in the body. By blocking the synthesis of prostaglandins, ibuprofen helps relieve symptoms associated with various conditions, such as headaches, menstrual pain, arthritis, and minor injuries.

Ibuprofen can be purchased without a prescription in different formulations, such as tablets, capsules and liquid suspensions. The recommended dose and duration of treatment may vary depending on the condition being treated and individual factors such as age and weight. It is important to follow the instructions provided by healthcare professionals or those indicated on the product packaging when taking ibuprofen.

  1. Ibuprofen relieves pain and reduces inflammation.
  2. It inhibits the production of prostaglandins, responsible for inflammation and pain.
  3. It is available in various forms such as tablets, capsules and liquid suspensions.

Common Brands of Ibuprofen
Brand Name
Advil Ibuprofen
Motrin Ibuprofen

“Ibuprofen can help relieve pain and reduce inflammation, but it is important to use it according to recommended guidelines.”- Medical professional

Understanding the Basics: What Ibuprofen Is and How It Works

Ibuprofen belongs to the class of NSAIDs, which are medications commonly used to relieve pain, reduce inflammation, and reduce fever. NSAIDs work by inhibiting the production of certain chemicals in the body called prostaglandins. These substances play a fundamental role in the body’s inflammatory response, which causes pain, swelling and fever. By reducing the production of prostaglandins, ibuprofen helps relieve these symptoms.

Important information:

  • Ibuprofen is commonly used to treat conditions such as headache, toothache, menstrual pain, muscle pain, arthritis, and fever.
  • It is available in various forms, such as tablets, capsules, liquid suspensions, and topically applied gels.
  • It is important to follow the recommended dosage and duration of use to avoid possible side effects and complications.
  • Some people may be at higher risk of adverse reactions, such as those with a history of stomach ulcers, kidney or liver disease, and asthma.

The mechanism of action of ibuprofen is to inhibit the enzyme called cyclooxygenase (COX). COX is responsible for the conversion of arachidonic acid into prostaglandins. There are two forms of COX: COX-1 and COX-2. COX-1 is involved in the production of prostaglandins. COX-1 is involved in the production of prostaglandins that maintain normal bodily functions, while COX-2 is primarily activated during the inflammatory response. Ibuprofen inhibits both COX-1 and COX-2, thereby reducing the overall production of prostaglandins and their associated inflammatory effects.

Advantages of ibuprofen: Disadvantages of Ibuprofen:
  • Effective in reducing pain and inflammation.
  • Quick onset of action.
  • Available without a prescription.
  • Available in multiple formulations for different needs.
  • Possible side effects such as stomach irritation, heartburn, and gastrointestinal bleeding.
  • May interact with other medications.
  • It is not suitable for everyone, such as those with certain medical conditions or allergies.
  • Its prolonged use can increase the risk of cardiovascular accidents.

The History of Ibuprofen: From Its Discovery to Widely Used Medication

1. Discovery:

The history of ibuprofen began in the 1950s, when a team of researchers at Boots Pure Drug Company in Nottingham, England, led by Dr. Stewart Adams, was working to develop a new range of compounds to treat various types of ibuprofen. of inflammatory conditions. After testing hundreds of chemical compounds, they discovered a substance known as 2-(4-isobutylphenyl) propionic acid that showed promising anti-inflammatory properties. This compound later became the basis for the development of ibuprofen.

Important information:

Dr. Stewart Adams and his team initially named the compound Brufen, derived from “BurtonFRom Nottingham”, the city where the company was based. However, this name was later changed to Ibuprofen.

2. Clinical trials and approval:

Following the discovery of the compound, extensive clinical trials were conducted to evaluate its safety and efficacy. Trials demonstrated its effectiveness in relieving pain and reducing inflammation, sparking great interest in the medical community. Consequently, ibuprofen received approval for use in the United Kingdom in 1969 and in the United States in 1974.

Important information:

Ibuprofen was the first no n-steroidal ant i-inflammatory that could be acquired without a medical recipe in the United States.

3. Popularity and diversification:

Once the ibuprofen was made available to the general public, its popularity shot due to its effectiveness and its relatively mild side effects compared to other analgesics. As a result, several pharmaceutical companies began to manufacture and market ibuprofen under different brands, which resulted in a wide range of options available for consumers.

Today, ibuprofen is not only used as analgesic and antipyretic, but also for its ant i-inflammatory properties. It has become a basic product in homes around the world, playing a crucial role in pain treatment and discomfort caused by various medical conditions.

  1. In 1969 the sale of ibuprofen was authorized in the United Kingdom under the Brufen brand.
  2. In 1974 his sale in the United States was authorized with the Motrin brand.
  3. Since then, different pharmaceutical companies have marketed several generic versions of ibuprofen.

In general, the history of ibuprofen highlights the importance of scientific research and development in the creation of innovative medicines that improve the wel l-being of people around the world.

Common Uses of Ibuprofen: Relieving Pain, Reducing Inflammation, and More

One of the most common uses of ibuprofen is the treatment of pain. It is already headache, teeth or menstrual pain, ibuprofen can provide effective relief acting on the source of pain and reducing the organism’s response to it. Its analgesic effects are due to the inhibition of prostaglandin production, chemical substances that favor inflammation and sensitization of pain receptors.

“Ibuprofen is usually used to relieve pain and reduce inflammation in various medical conditions.”

“Its analgesic effects are mediated by the inhibition of prostaglandin production.”

Ibuprofen is also frequently used to reduce inflammation. Inflammation is a natural response of the organism to an injury or infection, but it can be excessive and cause discomfort and tissue damage. By inhibiting the activity of enzymes called cyclooxygenas (COX), the ibuprofen interferes with the production of inflammatory mediators, such as prostaglandins and thromboxans.

  1. Alleviate the pain.
  2. Reduce inflammation.
  3. Control fever.
  4. Arthritis treatment.
  5. Relieve menstrual pains.

In addition to these common uses, ibuprofen has also been shown to be effective in controlling fever, treating arthritis, and relieving menstrual cramps. It is important to note that although ibuprofen is widely available and effective in relieving pain and inflammation in the short term, it is not indicated for long-term use without proper medical supervision. As with any medication, it is recommended that you consult a healthcare professional before starting ibuprofen or any other NSAID regimen.

Common uses of ibuprofen
Ease the pain
Reduce inflammation
Fever control
Arthritis treatment
Relieve menstrual pain

The Different Forms of Ibuprofen: Pills, Capsules, Liquids, and Topical Gels

Pills: One of the most common forms of ibuprofen is in pill form. These pills are usually taken orally with water and can be purchased over the counter or with a prescription. They are convenient and easy to swallow and provide a systemic effect, meaning they are absorbed into the bloodstream and distributed throughout the body. Some people prefer pills for their simplicity and familiarity.

  • Available in various concentrations, such as 200 mg and 400 mg.
  • They can take between 20 and 30 minutes to take effect.
  • They are usually taken every 4-6 hours, depending on the needs of each person and the recommended dose.

The pills are a popular choice for those looking for quick and complete pain relief.

Capsules: Ibuprofen capsules are another form of oral medication. Like tablets, capsules are taken orally with water. However, capsules may have different compositions, such as liquid-filled or gelatin-coated, which may affect their absorption and onset of action. The capsules offer a controlled release of ibuprofen, allowing for long-lasting pain relief.

  1. They are available in different concentrations such as 400 mg and 600 mg.
  2. They may take a little longer to take effect than tablets.
  3. They are generally taken every 6-8 hours, depending on the individual’s needs and the recommended dosage.

Comparison of forms of ibuprofen
Shape Administration Absorption Start of action Dosage
Pills Orally Systemic Approximately 20-30 minutes Every 4-6 hours
Capsules Orally Systemic May take longer than pills Every 6-8 hours

Dosage: The appropriate dose of ibuprofen depends on several factors, such as age, weight, and the disease being treated. It is always recommended to follow the instructions provided by the healthcare professional or the label on the container. In general, the suggested doses for adults and children over 12 years of age are as follows:

  • A unique dose of 200 to 400 milligrams (MG), with a maximum of 1, 200 mg in a period of 24 hours.
  • In case of intense pain, a higher initial dose can be taken, from 400 to 600 mg, followed by a lower maintenance dose.
  1. For children from 6 to 12 years, the dose should be determined depending on the child’s weight. The usual recommended dose is 5 to 10 mg per kilogram of body weight, up to a maximum of 1, 200 mg per day.
  2. For infants and children under 6 years, doses and security can vary. It is best to consult a healthcare professional to obtain adequate orientation.

Important note: Ibuprofen should not be used in children under 6 months without consulting a healthcare professional. Always use the lowest effective dose for the shortest possible time.

Ibuprofen vs. Other Pain Relievers: Understanding the Differences and Choosing the Right Option

Ibuprofen, a no n-steroidal ant i-inflammatory (NSAIDs), is widely used by its analgesic and ant i-inflammatory properties. It acts by reducing the production of chemical substances called prostaglandins, responsible for pain and inflammation in the body. Therefore, ibuprofen is an effective option to relieve various types of pain, such as headaches, menstrual, muscular and joint pain.

Important note: Ibuprofen should be taken with caution and under medical supervision, especially in the case of people with certain medical conditions such as stomach ulcers, kidney problems or cardiovascular diseases.

Although ibuprofen is a popular option to relieve pain, it is important to understand that it is not the only option available. Other common analgesics are paracetamol, aspirin and sodium naproxen. Each of these analgesics works differently and has its own advantages and limitations.


Paracetamol is a widely used analgesic that is effective in reducing mild to moderate pain and fever. Unlike ibuprofen, acetaminophen does not have ant i-inflammatory properties, so it is a better option for people who need to relieve pain but want to avoid possible irritation or stomach hemorrhage that NSAs can produce.

  • It acts by reducing the production of prostaglandins in the brain, which helps reduce the perception of pain and fever.
  • It is not recommended to people with liver diseases or who consume alcohol regularly, since it can damage the liver.


Aspirin is another analgesic of common use that also has ant i-inflammatory properties. It is usually used to relieve pain associated with headaches, menstrual pains and minor injuries. In addition, aspirin is usually prescribed by its anticoagulant properties in people at risk of myocardial infarctions or strokes.

  1. It acts inhibiting the production of prostaglandins, reducing pain and inflammation in the body.
  2. It can cause irritation or stomach hemorrhages, so it is not recommended to people with a history of stomach ulcers or hemorrhagic disorders.

Naproxen Sodium:

Sodium naproxen is a NSAID similar to ibuprofen and is usually used to relieve pain, inflammation and rigidity caused by conditions such as arthritis, menstrual pain and gout. Its action is more prolonged than that of ibuprofen, which means it provides relief for a longer time.

Characteristics Sodium naproxen Ibuprofen
Duration of action 8-12 hours 4-6 hours
Recommended dose 220-550 mg every 8-12 hours 200-400 mg every 4-6 hours
Greater risk of stomach ulcers Slightly superior Minor

Ultimately, the choice between ibuprofen and other analgesics depends on several factors, such as the type and severity of pain, possible side effects and individual medical history. It is always advisable to consult with a healthcare professional before starting to take any new medicine to ensure that the most appropriate option is chosen.

Author of the article
Dr.Greenblatt M.
Dr.Greenblatt M.
Medical oncologist at the Robert Larner College of Medicine, MD, at the University of Vermont

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