Discover the benefits of Mupirocin cream USP 2 and its effectiveness in the treatment of various skin infections. Learn more here.

Discover the benefits of USP 2 cream and its effectiveness in the treatment of various skin infections. Get more information here.

Mupirocin Cream USP 2 is a widely used topical antibiotic that offers effective treatment for various skin infections. It contains the active ingredient mupirocin, which belongs to the class of medications known as antibacterials. This cream is primarily prescribed by healthcare professionals to combat bacterial skin infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and other susceptible organisms.

  • Mupirocin cream is usually applied to the affected area of skin three times a day, or as directed by a healthcare professional.
  • It should be applied with a gentle massage until completely absorbed.
  • For optimal results, affected skin should be cleansed and dried before applying the cream.

Important note: Mupirocin cream should only be used externally, and should not be applied to the eyes, nose, mouth or any other part of the body. It is important to follow the prescribed duration of treatment, even if symptoms improve, to completely eradicate the infection and prevent it from recurring. Additionally, it is essential to wash your hands thoroughly before and after each application to prevent the spread of infection.

Mupirocin Cream USP 2 is available in different concentrations and should only be used under the supervision of a healthcare professional. It works by interrupting the production of proteins essential for the survival of bacteria, thus preventing their growth and spread. This cream is especially effective in the treatment of impetigo, a highly contagious skin infection that usually affects children. It also relieves other bacterial skin infections, such as folliculitis, furunculosis, and small infected wounds.

Advantages of Mupirocin Cream USP 2 Cons of Mupirocin Cream USP 2
  • Effective against various bacterial skin infections
  • Easy to apply and absorbs quickly
  • Minimal side effects if used as directed
  1. May cause a slight stinging, burning, or stinging sensation at the application site.
  2. Should not be used on open wounds or deep puncture wounds.
  3. Excessive or prolonged use can lead to the emergence of drug-resistant bacteria

Mupirocin Cream USP 2: An Effective Topical Treatment for Skin Infections

One of the main benefits of the USP 2 Cream Mugirocin is its ability to effectively treat a wide range of skin infections. It acts inhibiting protein synthesis in bacterial cells, preventing its growth and replication. This mechanism of action makes it an ideal option to treat both Gram-positive bacteria and some gram-negative, such as Staphylococcus aureus and Streptococcus pyogenes.


  • It contains mupirocina, an active substance that acts on bacteria and eliminates them.
  • Effective against various skin infections
  • Acts inhibiting protein synthesis in bacterial cells
  • It attacks both gram-positive and some gram-negative bacteria

In addition, the high power of the cream and its localized application makes it especially suitable for treating skin infections. As topical treatment, it can be applied directly to the affected area, which allows a concentrated and specific action. This helps to guarantee maximum efficiency while minimizing the risk of systemic side effects.

Understanding Mupirocin Cream USP 2: Composition and Mechanism of Action


  • Mipirocina: The active substance of the cream, the mupirocin, is a natural antibiotic derived from the fermentation product of pseudomonas fluorescens.
  • Polyethylene glycol: This ingredient serves as the basis of the cream and helps an easy application and absorption in the skin.
  • Mineral oil: acts as an emollient, providing moisturizing effects and ensuring that the cream extends evenly over the affected area.
  • Microcrystalline wax: This component contributes to the texture and consistency of the cream, allowing it to adhere to the skin and create a protective barrier.

Mechanism of action:

Cream mupirocin acts by inhibiting the synthesis of bacterial proteins, which leads to the suppression of bacterial growth and the subsequent eradication of the infection. It is mainly directed to specific enzymes known as isoleucil Transfer-Synthesas, which are essential for bacterial protein synthesis. Mugirocin binds irreversibly to these enzymes, preventing the incorporation of isoleucine into bacterial proteins and interrupting the normal functioning of bacterial cells.

The mechanism of action of the Mipirocin cream is unique and highly effective against a wide range of gram-positive bacteria, including Staphylococcus aureus and Streptococcus pyogenes.

In addition, mupirocin cream has been observed to have low systemic absorption, which minimizes the risks of adverse effects. However, it is essential to follow the prescribed dosage and application instructions provided by healthcare professionals, since incorrect or excessive use can reduce the effectiveness or develop resistance to antibiotics.

Summary of Mupirocin Cream USP 2: Composition and mechanism of action
Active ingredient Components Mechanism of action
Mupirocin Polyethylene glycol Inhibition of bacterial protein synthesis
Mineral oil
Microcrystalline wax

Understanding the composition and mechanism of action of mupirocin cream USP 2 provides valuable information regarding its therapeutic benefits and the rationale for its use in the treatment of skin infections. It is essential to consult healthcare professionals to obtain appropriate guidance and ensure responsible and effective use of this topical antibiotic.

Common Skin Infections Treated with Mupirocin Cream USP 2

One of the most common skin infections treated with Mupirocin Cream USP 2 is impetigo. Impetigo is a highly contagious bacterial infection characterized by red sores or blisters that may ooze fluid and form a honey-colored scab. It usually affects young children, especially those in close contact, such as daycare centers or schools. Mupirocin Cream USP 2 is applied topically to the affected area, eliminating the bacteria causing the infection and helping to prevent its spread.

Impetigo is a common skin infection caused primarily by the bacteria Staphylococcus aureus or Streptococcus pyogenes. To prevent the spread of infection, it is essential to maintain good hygiene practices, such as washing hands regularly and avoiding contact with infected people. Mupirocin Cream USP 2 should be applied three times a day for up to 10 days or as directed by a healthcare professional.

Another skin infection treated effectively with Mupirocin Cream USP 2 is folliculitis. Folliculitis is an inflammation of the hair follicles, usually due to a bacterial or fungal infection. It can lead to red, pimple-like bumps that may be itchy or painful. Mupirocin Cream USP 2 is applied directly to the affected follicles, inhibiting bacterial growth and reducing inflammation.

  1. Good personal hygiene is essential to prevent folliculitis. Showering regularly, using clean towels and clothing, and avoiding sharing personal items such as razors or scrubbers can help reduce the risk of infection.
  2. For people who participate in activities that may cause abrasions or skin irritation, such as sports or shaving, applying Mupirocin Cream USP 2 as a preventive measure may help reduce the likelihood of developing folliculitis.

How to Use Mupirocin Cream USP 2: Application Instructions and Precautions

Application instructions:

  1. Clean the affected area: Wash the affected skin with mild soap and water, making sure the area is clean before applying the cream. Dry with a clean towel.
  2. Apply a thin layer: Take a small amount of mupirocin cream and gently apply a thin layer to cover the affected area. Massage the cream until completely absorbed.
  3. Wash your hands after application: After applying the cream, wash your hands thoroughly to remove any remaining medication.
  4. Frequency of application: Your healthcare professional will determine the frequency of application based on the severity of the infection. Carefully follow your doctor’s instructions on how often to apply the cream.


  • Avoid contact with eyes, nose, mouth and other mucous membranes: Mupirocin cream should not be applied to these areas to avoid irritation and possible damage. In case of accidental contact, rinse with plenty of water.
  • Avoid using excessive amounts: Applying more cream than recommended will not improve the effectiveness of the medication, but it may increase the risk of side effects.
  • Do not cover with a bandage: Unless instructed to do so by your healthcare professional, it is generally recommended to leave the treated area uncovered to allow proper air circulation and absorption of the cream.

Note: This information does not replace the need to consult with a healthcare professional. Always follow your doctor’s instructions and read the product label carefully before using any medication.

Benefits and Effectiveness of Mupirocin Cream USP 2 in Treating Skin Infections

1. Broad spectrum of activity: Mupirocin Cream USP 2 has a broad spectrum of antibacterial activity, making it effective against a wide range of bacteria. It is commonly used to treat infections such as impetigo, a highly contagious skin condition caused by Staphylococcus bacteria. The cream can also effectively treat other types of skin infections caused by streptococcus and other bacteria.

“Mupirocin Cream USP 2 shows excellent activity against both Staphylococcus aureus and Streptococcus pyogenes, including strains resistant to other topical antibiotics.”

Source: Dermatology Times

2. Fast and specific action: Mupirocin Cream USP 2 is specifically designed to attack and eliminate bacteria on the surface of the skin. When applied as directed, the cream quickly penetrates the affected area, inhibiting bacterial protein synthesis and preventing further growth. This targeted action helps reduce inflammation, redness and discomfort associated with skin infections.

3. Low risk of resistance: Unlike other topical antibiotics, Mupirocin Cream USP 2 has a low risk of bacterial resistance. This is an essential factor in the treatment of skin infections, as antibiotic resistance is a growing concern in healthcare. Mupirocin’s unique mechanism of action makes it less prone to the development of resistance, ensuring its continued effectiveness in the treatment of skin infections.

Common uses of Mupirocin Cream USP 2:
1. Impetigo treatment
2. Treatment of secondary skin infections
3. Treatment of minor cuts and wounds
4. Prevention of infections in damaged skin areas

Potential Side Effects of Mupirocin Cream USP 2 and When to Seek Medical Attention

1. 1. Allergic reactions: Some individuals may experience allergic reactions to Mupirocin Cream USP 2. Symptoms of an allergic reaction can vary and may include skin rash, itching, redness, swelling, or severe dizziness. In severe cases, people may experience difficulty breathing or swallowing, which can be life-threatening and require immediate medical attention. If you suspect an allergic reaction to the cream, discontinue use and seek emergency medical help.

2. Skin irritation: Although rare, Mupirocin Cream USP 2 may cause skin irritation in some individuals. This may manifest as redness, itching, burning or stinging at the application site. If you experience persistent or worsening irritation, it is advisable to discontinue the cream and consult a healthcare professional for further guidance.

Common side effects of Mupirocin Cream USP 2 may include:
Side effects Frequency
Nausea Frequent (1-10% of users)
Headache Frequent (1-10% of users)
Diarrhea Frequent (1-10% of users)
Abdominal pain Frequent (1-10% of users)
Itching Uncommon (0. 1-1% of users)

It is important to note that the table above is not exhaustive and only includes some common side effects. If you experience any serious or unlisted side effects while using Mupirocin Cream USP 2, it is crucial that you seek immediate medical attention.

Comparing Mupirocin Cream USP 2 with Other Topical Antibiotic Treatments

1. Efficacy:

  • Mupirocin Cream USP 2: Mupirocin Cream USP 2 is known for its broad-spectrum activity against various gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Its mechanism of action consists of inhibiting the synthesis of bacterial proteins, preventing the growth and replication of bacteria.
  • Alternative topical antibiotics: Other topical antibiotics, such as neomycin and polymyxin B sulfates, also have antibacterial properties. However, their spectrum of activity may vary, and they may not be as effective against certain strains of bacteria.

Important note: It is essential to keep in mind that the choice of topical antibiotic treatment should be based on the susceptibility of the infecting bacteria, determined by laboratory tests. This ensures the selection of the most appropriate and effective treatment option.

2. Security profile:

  • Mupirocin Cream USP 2: Mupirocin Cream USP 2 is generally well tolerated and has a low incidence of adverse effects. However, like any medication, it can cause mild local skin reactions, such as a burning or stinging sensation.
  • Alternative topical antibiotics: Different topical antibiotics may have different safety profiles. For example, neomycin can cause allergic reactions in some people. It is essential to take into account individual patient factors (such as allergies or sensitivities) when selecting the most appropriate treatment option.

Comparative table summarizing key features of Mupirocin Cream USP 2 and alternative topical antibiotic treatments:

Topical antibiotic Effectiveness Security profile
Mupirocin Cream USP 2 Effective against gram-positive bacteria, including MRSA Generally well tolerated with minimal adverse effects
Neomycin Variable activity spectrum Possible allergic reactions
Polymyxin B sulfates Variable efficacy depending on the bacterial strain Possibility of skin irritation

Tips for Proper Storage and Shelf Life of Mupirocin Cream USP 2

  1. Store in a cool, dry place: It is crucial to store Mupirocin Cream USP 2 in a place that is not exposed to excessive heat or humidity. High temperatures and humidity can degrade the medication and affect its potency. Therefore, it is recommended to store the cream in a cool, dry place, away from direct sunlight.
  2. Check the expiration date: Like any other medicine, Mupirocin Cream USP 2 has a certain expiration date. It is important to check the expiration date on the packaging and avoid using the cream if it has expired. Expired medications may not be effective and potentially cause harm or unwanted side effects.
  3. Follow the container instructions: when storing USP 2 cream, the manufacturer’s instructions that appear in the container should be carefully followed. These instructions may include specific temperature ranges or storage conditions to maintain the stability and power of the cream.

Tips for properly conserving Mupirocin USP 2 cream
Tips Description
Keep in a fresh and dry place Avoid exposure to heat and humidity keeping the cream in a cool and dry place.
Check the expiration date Make sure the cream has not expired before using it for treatment.
Follow the instructions in the package Follow the manufacturer’s instructions to keep the cream in adequate conditions.

Adequate storage and manipulation of USP 2 Cream Mupirocin are essential to maintain its effectiveness and guarantee their safety of use. If it is not preserved correctly, its effectiveness can be reduced or caused. Always consult a health or pharmaceutical professional if you have any questions or doubt about the conservation or expiration of MUPIROCIN USP 2.

Author of the article
Dr.Greenblatt M.
Dr.Greenblatt M.
Medical oncologist at the Robert Larner College of Medicine, MD, at the University of Vermont

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